Engineering B Cell for Therapeutics Delivery: A Novel Medicine in Oncology

Over the past years, therapies using B cells for adoptive transfer have shown great promise for the treatment of cancers, infectious diseases, and autoimmune diseases. Many efforts have been made to engineer B cells to increase their therapeutic role.

Based on advanced technology and years of research, Creative Biolabs has developed a B cell engineering platform that creates B cells that can express therapeutic molecules. Our B cell engineering capabilities cover every stage from designing and synthesizing the requested cDNAs to editing your B cells. Our team has experience with genome editing in a large variety of cell types and also provides a one-stop solution for B cell engineering that is extremely efficient for site-specific knock-in of transgenes into a safe harbor locus in both B cell lines and primary B cells.

A Powerful B Cell Engineering Platform

To achieve safe, specific, and long-term therapeutic applications, B cells present a promising platform for the delivery of therapeutic antibodies/proteins. Here, we developed a one-stop solution for engineering B cell to deliver the necessary genes for treating diseases.

Engineering B Cell Types Engineering B Cell Types
We have built a powerful engineered human and murine B cell platform for therapeutic purposes such as protein replacement therapy or recombinant antibody production.
One-Stop Solution for B Cell Engineering One-Stop Solution for B Cell Engineering
Highly innovative genome editing technology platform including CRISPR/CAS9, and TALEN technology.
B Cell Engineering for Immunotherapy B Cell Engineering for Immunotherapy
Creative Biolabs provides a B cell gene therapy platform for therapeutic delivery, including therapeutic antibody delivery and therapeutic protein delivery.
Engineered B Cells Assessment Engineered B Cells Assessment
We also provide services to assess in vivo survival of these cells in a murine model, as well as phenotype, the protection effect and the ability to target antigen.
B Cell Differentiation Service B Cell Differentiation Service
We have extensive experience in identifying optimal conditions for differentiation of engineered B cells into long-lived antibody-secreting cells.
Integrated Solution Ranging From the Lab to the Clinic for Cancer Therapy

Creative Biolabs has developed a tailor-made B cell engineering service to support Labs, Biotechs, Medtech, and Pharma companies in their research program outsourcing. The new services combined with our expertise and values will accelerate the development of better cell and gene therapy.

B Cell Engineering Services

Project Options

Verification
  • Western Blot, Sanger sequencing or others

Existing services are adapted according to projects. Please feel free to contact us to discuss your project.

Start Your B Cell Engineering Project

B cell engineering has opened new possibilities in the area of cancer treatment. Creative Biolabs is pleased to offer an integrated solution to modify B cells for therapeutic delivery. Simply provide the B cells and the requested gene, then we’ll do the rest.

Workflow Client Provided Materials Service Portfolio Standard deliverables

Workflow of B cell engineering. (Creative Biolabs) Fig.1 Workflow of B cell engineering. (Creative Biolabs)

  • Cells to be edited. Clients can either provide their own source cells or available B cells can be provided by Creative Biolabs for an additional fee.
  • Gene sequence
  • Engineered B cells
  • Final report