This product is a Ramos (RA 1) B cell engineering tool based on the Nanoparticles (AS1411 aptamer/Nucleolin) delivery system and CRISPR-based (SHS-323-crRNA:tracrRNA duplex-Cas9-SCR7 pyrazine ) genome editor.
| Host Cell | Ramos (RA 1) |
| Target | GITR |
| Insert Clone | 3d6 |
| Safe Harbor Sites (SHS) | SHS-323 |
| gRNA | crRNA:tracrRNA duplex |
| Nuclease | Cas9 |
| Enhancer | SCR7 pyrazine |
| Targeting Strategy | Enzyme responsive |
| Insertion sites | Nonhomologous target sites |
| Vehicles | Nanoparticles |
| Ligand/Receptor | AS1411 aptamer/Nucleolin |
| Active Agents | AntimiR-21, doxorubicin (DOX) |
| Particle Size | <1000 |
| Charge (mv) | < 0 |
| Total Atom Count | ~65,000,000 |
| Surface Atoms (%) | ~0.6 |
| Specific Surface Area (m2/g) | ~0.8 |
| Vector Type | Baculovirus-AAV |
| Vector Name | BCpCDH4 |
| Targeting Diseases | Breast cancer; Lung cancer; Pancreatic cancer |
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