B cells, or B lymphocytes, play an important role in the adaptive immune response. One of their main roles is to produce antibodies (Ab), also known as immunoglobulins (Igs). When the body faces an infection, B cell cells release protective antibodies to protect the body from pathogens and rogue cells. Over the past few decades, many methods have emerged for engineering B cells, such as lentiviral (LV), which is commonly used to deliver transgenes into B cells for random insertion into the genome. Another example is the recent precision genome editing strategy, which uses homologous directed repair (HDR) to knock out or deliver transgenes to specific locations in the genome of B cells. Creative Biolabs offers a full-scale range of B cell engineering services to express specific antibodies against associated viruses or tumors. Creative Biolabs can provide more effective and convenient cell therapies for your immunology research.
Creative Biolabs introduces an alternative approach by developing comprehensive B cell engineering services that replace the endogenous-coding antibodies of primary human B cells with antibodies that target specific viruses and tumors. Efficient expression of engineered antibodies in primary B cells under the control of endogenous regulatory elements has been observed. Engineered cells also maintain normal antibody expression and secretion.
Fig.1 B cell engineering service for therapeutic antibody delivery. (Creative Biolabs)
Plasma B cells have the unique ability to secrete high levels of protein and have the potential to be used as protein-replacement-engineered cell therapies. Biologic antibody drugs are used to treat many diseases, including viruses, cancers, autoimmune diseases, and protein deficiencies.
Fig.2 Types of disease of therapeutic antibody delivery. (Creative Biolabs)
| B Cell Engineering Service for Anti-Viruses Antibody Delivery | B Cell Engineering Service for Anti-Tumor Antibody Delivery | B Cell Engineering Service for Anti-Autoimmune Diseases Antibody Delivery |
| Creative Biolabs provides proprietary B cell engineering services for anti-virus antibody delivery. Our engineered B cells secreted various antibodies that target a number of viruses, including COVID-19, HIV, RSV, Influenza Virus, and EBV. | Creative Biolabs provides proprietary B cell engineering services for anti-autoimmune disease antibody delivery. | |
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Our B cell engineering service for therapeutic antibody delivery can help researchers get insight into immunotherapy, and play an important role in the fields of infectious diseases, tumor microenvironment, and autoimmune disorders.
Fig.3 Features of B cell engineering service for therapeutic antibody delivery. (Creative Biolabs)
Q1. What are the factors affecting early antibody secreting cell (ASC) maturation into long-lived plasma cells (LLPCs)?
A: Intrinsic mechanisms involve anti-apoptosis, autophagy, and metabolism. Extrinsic factors include BM stromal cells, cytokines, and chemokines such as APRIL, IL-6, and CXCL12.
Professional consultation provides guidance before, during and after your B cell engineering project, please contact us for your tailored solution.