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β-hydroxybutyrylation-Specific Antibody Production Services

Based on the excellent High-Affi™ technology, Creative Biolabs has the capability of providing highly specific pan anti-β-hydroxybutyryllysine antibody and site-specific anti-β-hydroxybutyrylated protein antibodies production services. These antibodies are produced by optimized immunization with β-hydroxybutyrylated BSA or KLH or with a synthetic β-hydroxybutyryl peptide and purified by affinity chromatography. The pan anti-β-hydroxybutyryllysine antibody specifically recognizes proteins with β-hydroxybutyrylated lysine residues without species limitation, and site-specific anti-β-hydroxybutyrylated antibodies recognize site-specific β-hydroxybutyrylated peptide. They do not cross-react with non-modified lysine residues, unmodified peptides, 2-hydroxyisobutyrylated peptides and acetylated peptides.

Lysine β-hydroxybutyrylation (Kbhb) is a new identified histone post-translational modification in 2016 which is enriched in active gene promoters. It has been found to modify on many lysine residues of all four types of histones (H1, H2A, H2B, H3, H4).





Histone Kbhb marks are dramatically induced in response to elevated β-hydroxybutyrate levels in cultured cells and livers from mice subjected to prolonged fasting. Histone Kbhb is a mark enriched in active gene promoters during starvation and associated with genes upregulated in starvation-responsive metabolic pathways. Fig. 1. Metabolic regulation of gene expression by histone lysine β-hydroxybutyrylation. (Xie Z, et al. 2016)

However, the diverse effects of β-hydroxybutyrylation remain unclear. More work should be done to uncover the physiological functions of β-hydroxybutyrylation. Antibodies are the most common tools in PTM discovery, sites identification and functional study. Creative Biolabs can provide the global customers with the most comprehensive antibodies discovery and production services, especially in the field of PTM. The products are supplied with high affinity and 100% quality assurance.

Creative Biolabs can provide a comprehensive list of PTM-specific antibody production services of your choice.


Reference

  1. Xie Z, Zhang D, Chung D, et al. (2016) “Metabolic regulation of gene expression by histone lysine beta-hydroxybutyrylation”. Mol Cell, 62(2): 194-206.



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