Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights| Protein Name | Bradykinin receptor B1 |
| Gene Name | BDKRB1 |
| Uniprot | P46663 (Human); Q61125 (Mouse) |
| Synonym | B1R; BKR1; B1BKR; BKB1R; BRADYB1; BK-1 receptor; bradykinin B1 receptor; bradykinin receptor 1 |
| Background | Bradykinin is a nine-amino-acid peptide generated by kallikrein cleavage of kininogen precursor proteins in tissue and plasma. Two bradykinin receptors have been identified as mediators of bradykinin signaling: BDKRB1 and BDKRB2. These are cell surface, G-protein coupled receptors of the seven-transmembrane domain family. The human BDKRB1 receptor has a predicted sequence of 353 amino acids and is only 36% homologous to BDKRB2 receptors. The expression of BDKRB1 is induced during trauma, injury, and inflammation. It is best characterized as signaling via coupling to Gq alpha subunits (particularly Gq/11), leading to activation of phospholipase C beta, hydrolysis of PI, and an intracellular increase in free calcium. The BDKRB1 receptor is an inducible receptor, which can be rapidly upregulated in biological systems following some types of tissue injury. The expression of this receptor is reported to be induced by a variety of cytokines. |
Creative Biolabs offers comprehensive range of membrane protein products empowers your unique research needs.
| CAT# | Product Name | Expression System | Protein Length | Solubilizing Agents |
| S01YF-1023-KX300 | NativeExtract™ Human BDKRB1 Membrane Protein (Full length, Super Nanodisc) | HEK293 cell | Full length | Native Nanodisc |
| MPX3430K | MemDX™ Membrane Protein Human BDKRB1 Expressed in vitro E.coli expression system, Full Length | E.coli cell-free | Full length | Detergent |
| MP0116X | MemDX™ Membrane Protein Human BDKRB1 (Bradykinin receptor B1) for Antibody Discovery | Wheat germ cell-free | Full length | N/A |
| Please for more products or customization | ||||
L**a: Rapid delivery with detailed batch-specific documentation supported seamless integration into our GPCR signaling projects.
25/Mar/2023
E***n: Streamlined COA development accelerated our hypertension drug discovery pipeline.
27/Sep/2023
BDKRB1 Gene Therapy Development
We provide tailored solutions to meet your specific requirements. Please for more services.
Knock-In for BDKRB1 Gain-of-Function Mutations
Creative Biolabs offers knock-in services for BDKRB1 gain-of-function mutations. The precise integration of constitutively active BDKRB1 variants via homology-directed repair (HDR) represents a transformative approach to amplify receptor signaling in pathologies characterized by hypoactive pathways. For instance, in pre-clinical models of vascular dysfunction, gene-edited endothelial cells overexpressing hyperactive BDKRB1 alleles demonstrated enhanced nitric oxide release and vasodilation, thereby mitigating hypertension-related phenotypes. Creative Biolabs' proprietary RNA design platforms optimize HDR efficiency while minimizing off-target edits, ensuring translational fidelity for such interventions.
AAV-Delivered shRNA for BDKRB1 Silencing in Chronic Inflammatory Disorders
Creative Biolabs offers AAV-delivered shRNA services for BDKRB1 silencing in chronic inflammatory disorders. Adeno-associated virus (AAV) vectors engineered with tissue-specific promoters enable localized BDKRB1 knockdown in disease-relevant microenvironments. In murine models of rheumatoid arthritis, intra-articular delivery of AAV9-shBDKRB1 significantly reduced synovial inflammation and pain behaviors by attenuating bradykinin-mediated NF-κB activation. Creative Biolabs' expertise in AAV serotype optimization ensures targeted delivery to BDKRB1-rich tissues, such as synovium or lung epithelia.
Ex Vivo BDKRB1 Overexpression in HSCs
Creative Biolabs offers ex vivo BDKRB1 overexpression services. Ex vivo gene editing of HSCs to overexpress BDKRB1 has shown promise in ameliorating ischemia-reperfusion injury. Transplanted HSCs engineered via lentiviral vectors to express BDKRB1 upregulated pro-angiogenic factors like VEGF in ischemic limbs, accelerating tissue revascularization in diabetic models. Creative Biolabs' lentiviral transduction protocols, validated for minimal insertional mutagenesis, are ideal for such applications.
Creative Biolabs offers comprehensive and innovative services to drive the development of BDKRB1 cell therapy. Please for more services.
BDKRB1-Expressing CAR-T Cells for Solid Tumor Microenvironment Remodeling
Creative Biolabs offers BDKRB1-expressing CAR-T cells development services for solid tumor microenvironment remodeling. Chimeric antigen receptor (CAR)-T cells engineered to secrete BDKRB1 agonists offer dual mechanisms: direct tumor cytotoxicity and microenvironmental modulation. In pancreatic adenocarcinoma models, BDKRB1-activated CAR-T cells enhanced tumor permeability by inducing kinin-mediated vasodilation, improving T-cell infiltration, and chemotherapeutic efficacy. Creative Biolabs' CAR construct optimization services, including cytokine secretion profiling, ensure functional precision for such combinatorial therapies.
BDKRB1-Edited MSCs for Fibrosis Resolution
Creative Biolabs offers BDKRB1-edited MSCs development services for fibrosis resolution. Gene-edited MSCs with enhanced BDKRB1 expression secrete anti-fibrotic mediators, such as matrix metalloproteinases, to degrade pathological collagen deposits. In cirrhotic rat livers, BDKRB1-overexpressing MSCs reduced collagen density by 40% compared to wild-type counterparts, highlighting their potential for treating fibroproliferative diseases. Creative Biolabs' stem cell editing platforms, incorporating RNA-seq quality control, guarantee clonal uniformity and functional potency.
BDKRB1-Targeting Aptamer-Modified NK Cells for Enhanced Tumor Tropism
Creative Biolabs offers BDKRB1-targeting aptamer-modified NK cells development services for enhanced tumor tropism. Natural killer (NK) cells conjugated with BDKRB1-specific aptamers exhibit heightened tumor infiltration in BDKRB1-overexpressing malignancies. Preclinical glioblastoma data revealed that aptamer-guided NK cells reduced tumor volume by 60% via synergistic cytotoxicity and bradykinin pathway blockade. Creative Biolabs' aptamer screening pipelines identify high-affinity BDKRB1 binders, enabling precise cellular engineering.
Therapeutic targeting of BDKRB1 demands innovative gene and cell engineering strategies, from gene-editing precision to advanced viral vector design. Creative Biolabs' 20-year legacy in antibody and protein sciences equips us to deliver bespoke solutions for your most complex challenges. to schedule a strategic consultation—let us optimize your BDKRB1 therapeutic's efficacy, safety, and scalability. Your breakthrough starts with a conversation.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
