Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsWith over a decade of experience in phage display technology, Creative Biolabs can provide a series of antibody or peptide libraries that are available for licensing or direct screening. These ready-to-use libraries are invaluable resources for isolating target-specific binders for various research, diagnostic or therapeutic applications. Highlights
Creative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsAs an industry leader in antibody engineering field, experts from Creative Biolabs have developed CreativeAb™ antibodies in order to increase the efficacy of current therapeutic antibodies. Bispecific antibodies (BsAbs) are bioengineered antibodies that contain two different binding sites within a single molecule, which can specifically bind two different types of antigen. The most widely used application of bispecific antibody is in cancer immunotherapy, which creates a therapeutic treatment approach for diseases with specific medical needs.
Compared with traditional antibodies, bispecific antibodies have many advantages. The two arms can bring an antigen-expressing cell in close proximity to a killing cell and thus destroy the tumor cell; the two binding sites can significantly increase affinity or internalization rates of particular antigens on a cell's surface by binding to two different epitopes on an antigen; they usually have a higher cytotoxic potential to bind to antigens with low expression level. Binding tumor cells using a bispecific antibody-drug conjugate (ADC) also holds great promise for the future development of therapeutics for a variety of diseases.
With the development of antibody engineering, many types of bispecific antibodies have been designed to overcome short half-life, immunogenicity and side-effects caused by cytokine liberation. They include trifunctional antibodies, chemically linked Fabs, various types of bivalent and trivalent single chain variable fragments (scFvs), and fusion proteins mimicking the variable domains of two antibodies. The furthest developed of these newer formats are the bispecific T cell engagers (BiTEs) and mAb2's, antibodies engineered to contain an Fcab antigen-binding fragment instead of the Fc constant region.
We offer various types of bispecific antibodies:
Bispecific IgGs: CrossMab, KIH BsAb, etc.
Bispecific antibody fragments: Bispecific
single domain antibody, TandAb, Diabody, Triplebody, Bispecific intrabody, etc.
Bispecific fusion proteins: Bispecific antibody-HSA fusion proteins, Tandem scFv-toxin bispecific fusion protein, etc.
Bispecific antibody conjugates: IgG-IgG BsAb, Cov-X-Body, ScFv1-PEG-scFv2 BsAb
Based on various antibody formats such as IgGs, Fabs and scFvs, our Creative Discovery Platform™ provides a series of bispecific antibodies to satisfy various customers' needs. We provide construction (expression & purification) as well as recombinant antibody production at scales ranging from hundreds of micrograms to grams level.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
