Protein & Antibody related Conjugation Services
Introduction of Protein Conjugation
Protein conjugation is a widely used biological experimental technique that facilitates the covalent attachment of small molecules (such as drugs, haptens, and fluorescent dyes) or macromolecules (including enzymes, nucleotides, and polysaccharides) to proteins. This method is employed to prepare immunotoxins, synthetic antigens, fluorescent probes, enzyme-linked antibodies, antibody-drug conjugates, and glycoconjugate vaccines, among others. Typically, protein conjugation is achieved through specific functional groups, specifically the primary amine of lysine and the thiol group of cysteine. Additionally, crosslinking reagents can modify the amino acid side chains of proteins to create new functional groups, such as azides or dibenzocyclooctyne (DBCO) for click chemistry applications.
Creative Biolabs is committed to providing high-quality protein conjugation services for both research and industrial applications. We adhere to stringent quality control standards to ensure that each conjugate produced exhibits exceptional stability, specificity, and biological activity. Whether clients require antibody conjugation, biolabeling, or drug delivery systems, we offer comprehensive technical support and consulting services to effectively address various challenges encountered during experimental procedures.
Applications of Protein Conjugation
Protein conjugation technology has a broad range of applications in biomedical and scientific research, encompassing several key aspects:
- Detection and imaging
Labeling proteins with enzymes, fluorescent tags, or biotin significantly enhances the sensitivity and specificity of assays, facilitating diagnosis and imaging within biological samples.
- Drug delivery
Protein conjugation allows for the targeted delivery of drugs or toxins directly to specific cells or tissues. This approach is particularly beneficial in cancer treatment, where antibody-drug conjugates that bind to specific target proteins can significantly enhance therapeutic efficacy while minimizing side effects.
- Vaccine development
Glycoconjugate vaccines enhance the immune response by conjugating polysaccharide antigens from bacteria with carrier proteins. This process promotes the formation of polysaccharide-specific memory B cells, which are crucial for providing long-term immune protection against bacterial infections.
- Fundamental research
In foundational biological research, the utilization of fluorescent-labeled proteins or other labeling agents enables the observation of the localization and dynamics of specific proteins within cells.
Our Protein Conjugation Services
Drawing on years of accumulated experience in the field of protein conjugation, Creative Biolabs offers a diverse range of protein/antibody/peptide conjugation services to meet various research needs. Our offerings encompass multiple conjugation types, with detailed information available in the accompanying table. Additionally, we provide custom protein conjugation solutions tailored to specific client requirements, covering various conjugation chemistry methods and target protein selections.
Advantages of Our Services
Professional Team
Our team consists of experienced researchers and technical experts committed to providing high-quality protein bioconjugation services to our clients.
Advanced Equipment
We are equipped with state-of-the-art laboratory instruments that allow for the comprehensive characterization of conjugates using techniques such as UV-vis, HPLC, LC-MS, and NMR, ensuring the accuracy and reliability of our products.
Flexible Customization
We offer flexible customization services tailored to our clients' experimental requirements and research goals, meeting the specific needs and specifications of individual projects.
Comprehensive Support
We provide a one-stop service from consultation and experimental design to result analysis, ensuring that clients receive full support and guidance throughout the entire process.
Please contact us if you have any inquiries or requirements regarding our services for protein conjugation!