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Bispecific Immune Cell Engagers

Bispecific immune cell engagers (BiIE), such as T cell engagers and NK cell engagers, are special forms of tandem scFv. In which, one scFv binds to immune cells via the specific marker, such as CD3 of T cells, and the other scFv binds tumors via the tumor-associated antigen (TAA). This type of the molecules retarget immune cells to tumor cells and have shown great potentials in the studies of cancer therapy. Typical examples are blinatumomab (CD19-CD3, BiTE BLINCYTO®, Amgen), solitomab (EPCAM-CD3, Micromet AG) and pasotuxizumab (FOLH1-CD3, Micromet AG).

Scientists from Creative Biolabs have successfully constructed and engineered several bispecific immune cell engagers. Theoretically, bispecific immune cell engagers against any tumor marker can be constructed. Besides expression and purification of bispecific molecules, we can also provide ELISA/FACS binding assays, cell cytotoxic and apoptosis assays, etc.

Cat. No. Product Name scFv1 scFv2
CBL-BiIE001-01 CEA-CD3 BiIE OKT3 (Original) Anti-CEA scFv
CBL-BiIE001-11 CEA-CD3 BiIE OKT3 (Revised) Anti-CEA scFv
CBL-BiIE002-01 EPCAM-CD3 BiIE OKT3 (Original) Anti-EPCAM scFv
CBL-BiIE002-11 EPCAM-CD3 BiIE OKT3 (Revised) Anti-EPCAM scFv
CBL-BiIE003-01 EGFR-CD3 BiIE OKT3 (Original) Cetuximab scFv
CBL-BiIE003-11 EGFR-CD3 BiIE OKT3 (Revised) Cetuximab scFv
CBL-BiIE003-02 EGFR-CD3 BiIE OKT3 (Original) Panitumumab scFv
CBL-BiIE003-12 EGFR-CD3 BiIE OKT3 (Revised) Panitumumab scFv
CBL-BiIE005-01 CD19-CD3 BiIE OKT3 (Original) Anti-CD19 scFv
CBL-BiIE005-11 CD19-CD3 BiIE OKT3 (Revised) Anti-CD19 scFv
CBL-BiIE008-01 HER2-CD3 BiIE OKT3 (Original) Trastuzumab scFv
CBL-BiIE008-11 HER2-CD3 BiIE OKT3 (Revised) Trastuzumab scFv
CBL-BiIE008-02 HER2-CD3 BiIE OKT3 (Original) Pertuzumab scFv
CBL-BiIE008-12 HER2-CD3 BiIE OKT3 (Revised) Pertuzumab scFv
CBL-BiIE009-01 sTn-CD3 BiIE OKT3 (Original) Anti-sTn scFv
CBL-BiIE009-11 sTn-CD3 BiIE OKT3 (Revised) Anti-sTn scFv
CBL-BiIE009-12 CD20-CD3 BiIE OKT3 (Original) Anti-CD20 scFv
CBL-BiIE009-13 CD20-CD3 BiIE OKT3 (Revised) Anti-CD20 scFv
CBL-BiIE009-16 CD33-CD3 BiIE OKT3 (Original) Anti-CD33 scFv
CBL-BiIE009-17 CD33-CD3 BiIE OKT3 (Revised) Anti-CD33 scFv
CBL-BiIE009-18 CD133-CD3 BiIE OKT3 (Original) Anti-CD133 scFv
CBL-BiIE009-19 CD133-CD3 BiIE OKT3 (Revised) Anti-CD133 scFv
CBL-BiIE009-20 PSMA-CD3 BiIE OKT3 (Original) Anti-PSMA scFv
CBL-BiIE009-21 PSMA-CD3 BiIE OKT3 (Revised) Anti-PSMA scFv
CBL-BiIE009-22 CD30-CD3 BiIE OKT3 (Original) Anti-CD30 scFv
CBL-BiIE009-23 CD30-CD3 BiIE OKT3 (Revised) Anti-CD30 scFv
CBL-BiIE009-24 CD47-CD3 BiIE OKT3 (Original) Anti-CD47 scFv
CBL-BiIE009-25 CD47-CD3 BiIE OKT3 (Revised) Anti-CD47 scFv
CBL-BiIE009-26 CD52-CD3 BiIE OKT3 (Original) Anti-CD52 scFv
CBL-BiIE009-27 CD52-CD3 BiIE OKT3 (Revised) Anti-CD52 scFv
CBL-BiIE009-28 gpA33-CD3 BiIE OKT3 (Original) Anti-gpA33 scFv
CBL-BiIE009-29 gpA33-CD3 BiIE OKT3 (Revised) Anti-gpA33 scFv
CBL-BiIE009-30 TAG-72-CD3 BiIE OKT3 (Original) Anti-TAG-72 scFv
CBL-BiIE009-31 TAG-72-CD3 BiIE OKT3 (Revised) Anti-TAG-72 scFv
CBL-BiIE009-32 Mucin-CD3 BiIE OKT3 (Original) Anti-Mucin scFv
CBL-BiIE009-33 Mucin-CD3 BiIE OKT3 (Revised) Anti-Mucin scFv
CBL-BiIE009-34 CIX-CD3 BiIE OKT3 (Original) Anti-CIX scFv
CBL-BiIE009-35 CIX-CD3 BiIE OKT3 (Revised) Anti-CIX scFv
CBL-BiIE009-36 PSMA-CD3 BiIE OKT3 (Original) Anti-PSMA scFv
CBL-BiIE009-37 PSMA-CD3 BiIE OKT3 (Revised) Anti-PSMA scFv
CBL-BiIE009-38 GD2-CD3 BiIE OKT3 (Original) Anti-GD2 scFv
CBL-BiIE009-39 GD2-CD3 BiIE OKT3 (Revised) Anti-GD2 scFv
CBL-BiIE009-40 GD3-CD3 BiIE OKT3 (Original) Anti-GD3 scFv
CBL-BiIE009-41 GD3-CD3 BiIE OKT3 (Revised) Anti-GD3 scFv
CBL-BiIE009-42 GM2-CD3 BiIE OKT3 (Original) Anti-GM2 scFv
CBL-BiIE009-43 GM2-CD3 BiIE OKT3 (Revised) Anti-GM2 scFv
CBL-BiIE009-44 VEGFR-CD3 BiIE OKT3 (Original) Anti-VEGFR scFv
CBL-BiIE009-45 VEGFR-CD3 BiIE OKT3 (Revised) Anti-VEGFR scFv
CBL-BiIE009-46 Integrin-CD3 BiIE OKT3 (Original) Anti-Integrin scFv
CBL-BiIE009-47 Integrin-CD3 BiIE OKT3 (Revised) Anti-Integrin scFv
CBL-BiIE009-48 MET-CD3 BiIE OKT3 (Original) Anti-MET scFv
CBL-BiIE009-49 MET-CD3 BiIE OKT3 (Revised) Anti-MET scFv
CBL-BiIE009-50 IGF1R-CD3 BiIE OKT3 (Original) Anti-IGF1R scFv
CBL-BiIE009-51 IGF1R-CD3 BiIE OKT3 (Revised) Anti-IGF1R scFv
CBL-BiIE009-52 EPHA3-CD3 BiIE OKT3 (Original) Anti-EPHA3 scFv
CBL-BiIE009-53 EPHA3-CD3 BiIE OKT3 (Revised) Anti-EPHA3 scFv
CBL-BiIE009-54 TRAILR1-CD3 BiIE OKT3 (Original) Anti-TRAILR1 scFv
CBL-BiIE009-55 TRAILR1-CD3 BiIE OKT3 (Revised) Anti-TRAILR1 scFv
CBL-BiIE009-56 TRAILR2-CD3 BiIE OKT3 (Original) Anti-TRAILR2 scFv
CBL-BiIE009-57 TRAILR2-CD3 BiIE OKT3 (Revised) Anti-TRAILR2 scFv
CBL-BiIE009-58 RANKL-CD3 BiIE OKT3 (Original) Anti-RANKL scFv
CBL-BiIE009-59 RANKL-CD3 BiIE OKT3 (Revised) Anti-RANKL scFv
CBL-BiIE009-60 FAP-CD3 BiIE OKT3 (Original) Anti-FAP scFv
CBL-BiIE009-61 FAP-CD3 BiIE OKT3 (Revised) Anti-FAP scFv
CBL-BiIE009-62 Tenascin-CD3 BiIE OKT3 (Original) Anti-Tenascin scFv
CBL-BiIE009-63 Tenascin-CD3 BiIE OKT3 (Revised) Anti-Tenascin scFv

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