{"id":1564,"date":"2020-09-02T02:21:17","date_gmt":"2020-09-02T07:21:17","guid":{"rendered":"http:\/\/www.creative-biolabs.com\/blog\/?p=1564"},"modified":"2022-05-06T02:36:28","modified_gmt":"2022-05-06T07:36:28","slug":"covid-19-may-lead-to-the-loss-of-important-immune-structure-it-is-expected-to-explain-the-cause-of-secondary-infection-in-recovered-patients","status":"publish","type":"post","link":"https:\/\/www.creative-biolabs.com\/blog\/index.php\/covid-19-may-lead-to-the-loss-of-important-immune-structure-it-is-expected-to-explain-the-cause-of-secondary-infection-in-recovered-patients\/","title":{"rendered":"COVID-19 May Lead to the Loss of Important Immune Structure\u2014It Is Expected to Explain the Cause of Secondary Infection in Recovered Patients"},"content":{"rendered":"

According to the latest report from the Science<\/em>, four research institutions, including Massachusetts Institute of Technology and Harvard University, conducted an autopsy analysis on patients who died of COVID-19 and found that the deceased lacked a germinal center (GC). This discovery may help explain the development process of COVID-19 in severely ill patients and provide some inspiration for vaccine developers. At the same time, it may become a breakthrough in understanding the secondary infection of COVID-19.<\/p>\n

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Germinal center is a unique microstructure in which effector B cells secreting antibodies can mature and improve their antibody response<\/a><\/span><\/strong> to the virus. Therefore, it can also be seen vividly as a “classroom” for immune cells that exist in the spleen and lymph nodes to “learn” how to enhance the long-term immune response to pathogens.<\/p>\n

In the experiment, the researchers examined the spleen and thoracic lymph nodes of 11 patients who died of COVID-19 and compared them with 6 tissues from other patients of the same age and died of other causes. Under normal circumstances, these tissues should gather antibody-secreting B cells to form new germinal centers, but no such structure was found in COVID-19 patients, which surprised the researchers. This coincides with the results of another experiment, which confirmed that there was a serious lack of antibody immune response in COVID-19\u2019s deceased body.<\/p>\n

The experimental results showed that the cytokine storm and tumor necrosis factor (TNF) in the lymph nodes of the deceased of COVID-19 were significantly higher than those of the control group. In addition, there was also a loss of T cells that played a major role in the formation of a germinal center in the deceased of COVID-19. Based on the results of mouse experiments, the researchers suspected that this was related to the inhibitory effect of excessive TNF.<\/p>\n

These findings will provide important implications for vaccine developers: excessive TNF in lymph nodes will prevent the immune effect of the vaccine from lasting for a long time. At the same time, this discovery may explain why recovered patients are infected with novel coronavirus for the second time. As it is difficult to form a germinal center after infection with novel coronavirus and immune memory cells are affected, it is still possible to re-infect novel coronavirus after the patient is immunized with the virus for the first time.<\/p>\n","protected":false},"excerpt":{"rendered":"

According to the latest report from the Science, four research institutions, including Massachusetts Institute of Technology and Harvard University, conducted an autopsy analysis on patients who died of COVID-19 and found thatRead More…<\/a><\/p>\n","protected":false},"author":1,"featured_media":1566,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1,112],"tags":[167,171,24],"_links":{"self":[{"href":"https:\/\/www.creative-biolabs.com\/blog\/index.php\/wp-json\/wp\/v2\/posts\/1564"}],"collection":[{"href":"https:\/\/www.creative-biolabs.com\/blog\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.creative-biolabs.com\/blog\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.creative-biolabs.com\/blog\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.creative-biolabs.com\/blog\/index.php\/wp-json\/wp\/v2\/comments?post=1564"}],"version-history":[{"count":2,"href":"https:\/\/www.creative-biolabs.com\/blog\/index.php\/wp-json\/wp\/v2\/posts\/1564\/revisions"}],"predecessor-version":[{"id":1789,"href":"https:\/\/www.creative-biolabs.com\/blog\/index.php\/wp-json\/wp\/v2\/posts\/1564\/revisions\/1789"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.creative-biolabs.com\/blog\/index.php\/wp-json\/wp\/v2\/media\/1566"}],"wp:attachment":[{"href":"https:\/\/www.creative-biolabs.com\/blog\/index.php\/wp-json\/wp\/v2\/media?parent=1564"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.creative-biolabs.com\/blog\/index.php\/wp-json\/wp\/v2\/categories?post=1564"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.creative-biolabs.com\/blog\/index.php\/wp-json\/wp\/v2\/tags?post=1564"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}