Proteins with short lifespans control gene expression in cells and perform many crucial tasks, from aiding in brain connectivity to assisting the body in immune defense. These proteins are produced in theRead More…
PROTAC, proteolysis targeting chimera, or proteolytic targeted chimera, is a new type of drug different from antibodies and traditional small molecule inhibitors. PROTAC consists of target protein binder, linker, and E3 ubiquitinRead More…
In 2004, the Nobel Prize in Chemistry was awarded to Israeli scientists Aaron Sichanova, Afram Hershko and American scientist Irwin Ross for their discovery of ubiquitin-regulated protein degradation. Protein degradation is ratedRead More…
In recent years, targeted protein degradation chimera (PROTAC) as a novel way to induce protein degradation has become a new drug discovery strategy. Compared with traditional protein inhibitor drugs, it has uniqueRead More…
PROTACs is a novel technique in protein drug research field. Unlike traditional protein inhibitors, PROTACs are potential to target undruggable protein. Therefore, it has become a potential cancer therapy strategy. PROTACs appearsRead More…