Nef is an accessory protein encoded by HIV-1, HIV-2, and other primate lentiviruses and is closely related to viral replication, persistent infection, and the development of AIDS. Nef interacts with a varietyRead More…
Over the past two decades, protein-targeting degradation technologies (TPD), epitomized by Protein Degrader (proteolysis targeting chimera), have undergone rapid development and are considered one of the most promising breakthrough technologies for tacklingRead More…
ROTAC technology has advantages such as targeting non-druggable targets, high catalytic activity, and overcoming drug resistance, making it a new strategy in drug development. Traditional Protein Degrader design and synthesis require aRead More…
In Alzheimer’s disease, fibrous tau pathology accumulates and spreads in the brain, leading to synaptic loss. Researchers studying mouse models have found that tau protein can spread from presynaptic to postsynaptic synapses,Read More…
Proteins with short lifespans control gene expression in cells and perform many crucial tasks, from aiding in brain connectivity to assisting the body in immune defense. These proteins are produced in theRead More…
In a new study, researchers from the University of Oxford, the University of Cambridge, and the Pirbright Institute in the UK have discovered a novel therapeutic approach to investigating how poxviruses evadeRead More…
The ubiquitin-proteasome system is one of the main pathways for cellular protein degradation. In recent years, methods for artificially degrading target proteins through UPS have been developed. Targeted protein degradation agents areRead More…
Compared with traditional drugs, Protein Degrader molecules have many advantages. Protein Degrader molecule is covalently linked by the target protein ligand and E3 ubiquitin ligase ligand. After binding to the target protein,Read More…
Protein Degrader technology, by linking E3 ubiquitin ligase to the target protein, leads to the ubiquitin modification of the target protein which is broken down into peptides and amino acids by proteasome.Read More…
New lung cancer diagnoses and deaths have decreased as a result of reduced smoking and advances in early screening and treatment. However, lung cancer remains the leading cause of cancer deaths, accountingRead More…