11Apr/22

E3 Ligase, Critical for Protein Degrader Design

April 11, 2022Protein Degrader ReviewsE3 ligase, Targeted Protein Degraderbiolabs

A core factor of Protein Degrader molecules is that protein degradants can be designed rationally by selecting ligase molecules and linkers according to the target. The module that binds to E3 ligaseRead More…

28Feb/22

Protein Degraders-Induced Protein Degradation ─ A New Model in Drug Discovery

February 28, 2022Protein Degrader ReviewsCereblon, MDM2, Protein Degrader reviewbiolabs

Protein Degrader Concept Protein Degraders has become a new model of drug discovery, with the potential to change traditional drug discovery, and may become a new blockbuster therapy. Protein Degraders is aRead More…

28Feb/22

Nature: Development Directions of Protein Degrader Targeted Protein Degradation Technology in the Next 20 Years

February 28, 2022Protein Degrader ReviewsAntiviral Protein Degraders, E3 ligases, Targeted Protein Degraderbiolabs

It took nearly 20 years for Protein Degrader technology to transform from academia to preclinical and clinical drug development projects. In 2019, Protein Degrader obtained the clinical proof of concept in oncologyRead More…

20Jan/22

Cell: More han 100 Potential Protein Degrader Targets Revealed

January 20, 2022Protein Degrader ReviewsAKT1, BTK, CDK9, DAPK1, Protein Degrader targetsbiolabs

There are about 514 different protein kinases operating in human cells, accounting for 2.5% of the entire human genome. For scientists who want to use targeted protein degradation (TPD) technology to destroyRead More…

16Nov/21

Protein Degrader “modified” molecular glue—MDM2 degrader can degrade p53

November 16, 2021Protein Degrader Research, Protein Degrader ReviewsE3 ubiquitin ligase, MDM2 degrader, Targeted Protein Degraderbiolabs

Protein Degraders, also named as Proteolysis-Targeting Chimeras, is a new type of drug that is different from antibodies and traditional small molecular inhibitors. It consists of target proteins ligand, linker, and E3Read More…

21Oct/21

Blockbuster: 1336 Protein Degrader targets revealed in Nature

October 21, 2021Protein Degrader Reviewsprotein degradationbiolabs

Protein Degrader, proteolysis targeting chimera, or proteolytic targeted chimera, is a new type of drug different from antibodies and traditional small molecule inhibitors. Protein Degrader consists of target protein binder, linker, andRead More…

08Jul/21

Promising Protein Degrader: The latest global R&D progress

July 8, 2021Protein Degrader ReviewsProtein Degrader targets, Protein-degraders, undruggable molecularbiolabs

Over the past decade, major changes have taken place in the field of drug targets. Although the traditional target is still the main direction, the R&D trend is gradually shifting from traditionalRead More…

24Mar/21

Pros and Cons of Protein Degrader Technology

March 24, 2021Protein Degrader ReviewsProtein Degrader Technologybiolabs

Advantages of Protein Degrader technology   Through Protein Degrader technology, it is possible to develop drugs against undruggable or difficult-to-drug targets of traditional inhibitors. The Protein Degrader does not rely on theRead More…

24Mar/21

Protein Degrader, a Frontier Small Molecule Drug

March 24, 2021Protein Degrader Research, Protein Degrader ReviewsArvinas, CRBN, E3 ligase, Targeted Protein Degrader, VHLbiolabs

On December 14, 2020, Arvinas, a pioneer of Protein Degrader, announced the results of phase I clinical trials of new Protein Degrader drugs ARV-471 and ARV-110, of which ARV-471 showed outstanding efficacyRead More…

31Jan/21

Protein Degrader–Opportunities and Challenges

January 31, 2021Protein Degrader ReviewsE3 ubiquitin ligase, Targeted Protein Degrader, ubiquitin-proteasome systembiolabs

Protein Degrader is a novel technique that induces targeted protein degradation by the ubiquitin-proteasome system (UPS). Different from the traditional occupation-driven pharmacological principles, event-driven Protein Degrader technology has many advantages, such asRead More…