20Jan/22

Cell: More han 100 Potential Protein Degrader Targets Revealed

January 20, 2022Protein Degrader ReviewsAKT1, BTK, CDK9, DAPK1, Protein Degrader targetsbiolabs

There are about 514 different protein kinases operating in human cells, accounting for 2.5% of the entire human genome. For scientists who want to use targeted protein degradation (TPD) technology to destroyRead More…

16Nov/21

Protein Degrader “modified” molecular glue—MDM2 degrader can degrade p53

November 16, 2021Protein Degrader Research, Protein Degrader ReviewsE3 ubiquitin ligase, MDM2 degrader, Targeted Protein Degraderbiolabs

Protein Degraders, also named as Proteolysis-Targeting Chimeras, is a new type of drug that is different from antibodies and traditional small molecular inhibitors. It consists of target proteins ligand, linker, and E3Read More…

21Oct/21

Blockbuster: 1336 Protein Degrader targets revealed in Nature

October 21, 2021Protein Degrader Reviewsprotein degradationbiolabs

Protein Degrader, proteolysis targeting chimera, or proteolytic targeted chimera, is a new type of drug different from antibodies and traditional small molecule inhibitors. Protein Degrader consists of target protein binder, linker, andRead More…

08Jul/21

Promising Protein Degrader: The latest global R&D progress

July 8, 2021Protein Degrader ReviewsProtein Degrader targets, Protein-degraders, undruggable molecularbiolabs

Over the past decade, major changes have taken place in the field of drug targets. Although the traditional target is still the main direction, the R&D trend is gradually shifting from traditionalRead More…

24Mar/21

Pros and Cons of Protein Degrader Technology

March 24, 2021Protein Degrader ReviewsProtein Degrader Technologybiolabs

Advantages of Protein Degrader technology   Through Protein Degrader technology, it is possible to develop drugs against undruggable or difficult-to-drug targets of traditional inhibitors. The Protein Degrader does not rely on theRead More…

24Mar/21

Protein Degrader, a Frontier Small Molecule Drug

March 24, 2021Protein Degrader Research, Protein Degrader ReviewsArvinas, CRBN, E3 ligase, Targeted Protein Degrader, VHLbiolabs

On December 14, 2020, Arvinas, a pioneer of Protein Degrader, announced the results of phase I clinical trials of new Protein Degrader drugs ARV-471 and ARV-110, of which ARV-471 showed outstanding efficacyRead More…

31Jan/21

Protein Degrader–Opportunities and Challenges

January 31, 2021Protein Degrader ReviewsE3 ubiquitin ligase, Targeted Protein Degrader, ubiquitin-proteasome systembiolabs

Protein Degrader is a novel technique that induces targeted protein degradation by the ubiquitin-proteasome system (UPS). Different from the traditional occupation-driven pharmacological principles, event-driven Protein Degrader technology has many advantages, such asRead More…

31Jan/21

A Deeper Look into Protein Degrader Technology

January 31, 2021Protein Degrader ReviewsProtein Degrader Technology, Protein-degradersbiolabs

Over the past decade, major changes have taken place in the field of drug targets. Although traditional targets (such as kinases and G-protein-coupled receptors) are still the main stream, the focus isRead More…

30Nov/20

Focus on Protein Degrader—Target Summary from 2001 to 2019

November 30, 2020Protein Degrader ReviewsProtein Degrader, Protein Degrader Targetbiolabs

Protein Degrader, of which the full name is proteolysis-targeting chimera, looks like a dumbbell and mainly consists of a linker, a ligand of interest protein, and a ligand recruiting E3 ubiquitin ligase.Read More…