The landscape of cancer treatment is undergoing a fundamental shift, moving beyond traditional methods of protein inhibition toward a more profound and comprehensive therapeutic strategy: targeted protein degradation (TPD). This innovative approachRead More…
Endocrine therapy has long been a vital treatment option for estrogen receptor-alpha (ERα)-positive breast cancer. However, the frequent clinical problem of endocrine therapy resistance has left many patients in a difficult situation. This is particularly true whenRead More…
For decades, the primary strategy in drug development has been one of inhibition. We design molecules to block the function of harmful proteins, fitting into their active sites like a key inRead More…
Proteolysis-targeting chimeras function by recruiting ubiquitin ligases to targeted intracellular proteins, which promotes the degradation of pathogenic proteins via the proteasome system. This has made many previously “undruggable” proteins into viable therapeuticRead More…
In the ever-evolving landscape of medical research, protein degraders have emerged as a revolutionary class of therapeutic agents. Targeted protein degradation has rapidly expanded as a promising approach in drug discovery, openingRead More…
In the ever-evolving landscape of biomedical research, targeted protein degradation (TPD) has emerged as a transformative approach with the potential to redefine disease treatment. By selectively eliminating pathogenic proteins, this technology addressesRead More…
Hello, fellow science enthusiasts! Today, we’re diving into the fascinating world of cancer therapeutics, where the quest for precision and efficacy is ever-evolving. Groundbreaking research has introduced a novel approach to tackleRead More…
Traditional chemotherapy has been a vital tool in cancer treatment for decades, targeting rapidly dividing cancer cells. However, its lack of specificity leads to significant side effects, and drug resistance remains aRead More…
When we think about next-gen therapies that eliminate disease-causing proteins, most attention goes to the “targeting” components—the parts that bind to harmful proteins or cellular cleanup crews. But there’s a quiet powerhouseRead More…
Drug discovery is experiencing an unobtrusive revolution. Researchers have advanced past just blocking dangerous proteins and now pursue methods to actively break them down which could enable treatments for previously untreatable diseases. The foundationRead More…