Recombinant Anti-Ad fiber knob x Anti-CD40 Bispecific Antibody (F(ab')2-scFv2) (BABFV-002)

Recombinant Anti-Ad fiber knob x Anti-CD40 Bispecific Antibody (F(ab')2-scFv2) is designed to be expressed as two chains combined via a hinge region. The scFv of the anti-Ad fiber knob specificity is fused to the C terminus of the anti-CD40 Fab fragment, or vice versa. This format comprises four binding sites (two same scFv regions and two same Fab fragments), two for each antigen. This BsAb can retarget of adenoviral vectors to tumour cells. It can be used in cancer gene therapy to transfer a therapeutic gene into tumour cells aiming at selective and efficient cell killing.

Datasheet INQUIRY

Specifications

Targets

Ad fiber knob & CD40

Type

Fab-Fc Fusion Proteins

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Acute myeloid leukaemic (AML)

Targets

Target 1

Ad fiber knob

Alternative Names

Ad fiber knob; Adenovirus fiber knob; adenovirus fiber protein; knob domain of Ad fiber

Target 2

CD40

Gene ID

958

UniProt ID

P25942

Alternative Names

CD40; CD40 molecule; p50; Bp50; CDW40; TNFRSF5

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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Recombinant Anti-Ad fiber knob x Anti-CD40 Bispecific Antibody (F(ab')2-scFv2) (CAT#: BABFV-002)

Specifications

Targets

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