Recombinant Anti-Ad fiber knob x Anti-CD40 Bispecific Antibody (Fab-IgG) (FABIG-002)

Recombinant Anti-Ad fiber knob x Anti-CD40 Bispecific Antibody (Fab-IgG) is designed to be expressed as three chains, assembling in vivo and resulting in the construct of Fab-IgG (Tandem Fab-Fc). Fab-IgG has standard Fab and Fc domains, with no mutations, which may permit it has similar affinity binding and PK profile comparable to the parental antibodies. This BsAb can retarget of adenoviral vectors to tumour cells. It can be used in cancer gene therapy to transfer a therapeutic gene into tumour cells aiming at selective and efficient cell killing.

Datasheet INQUIRY

Specifications

Targets

Ad fiber knob & CD40

Type

Fab-IgG

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Acute myeloid leukaemic (AML)

Targets

Target 1

Ad fiber knob

Alternative Names

Ad fiber knob; Adenovirus fiber knob; adenovirus fiber protein; knob domain of Ad fiber

Target 2

CD40

Gene ID

958

UniProt ID

P25942

Alternative Names

CD40; CD40 molecule; p50; Bp50; CDW40; TNFRSF5

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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Recombinant Anti-Ad fiber knob x Anti-CD40 Bispecific Antibody (Fab-IgG) (CAT#: FABIG-002)

Specifications

Targets

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