Anti-Ad fiber knob x Anti-CD40 Bispecific Antibody (IgG-IgG) is designed to be generated by crosslinking two full length IgGs, anti-Ad fiber knob and anti-CD40 parental antibodies. A stable linkage is formed between the two antibodies. This BsAb can retarget of adenoviral vectors to tumour cells. It can be used in cancer gene therapy to transfer a therapeutic gene into tumour cells aiming at selective and efficient cell killing.
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