Recombinant Anti-Ad fiber knob x Anti-CEA Bispecific Antibody (Bibody)  (BIBD-003)

Recombinant Anti-Ad fiber knob x Anti-CEA Bispecific Antibody (Bibody) is a Fab-scFv format that uses heterodimeric Fab as a scaffold, and a scFv region linked to one of its heavy (Fd) or light (L) chain. The scFv of the anti-Ad fiber knob specificity is fused to the anti-CEA heavy or light chain of the Fab. This BsAb can retarget of adenoviral vectors to tumour cells. It can be used in cancer gene therapy to transfer a therapeutic gene into tumour cells aiming at selective and efficient cell killing.

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