Recombinant Anti-Ad fiber knob x Anti-CEA Bispecific Antibody (Fab-Fv) (FABFV-003)

Recombinant Anti-Ad fiber knob x Anti-CEA Bispecific Antibody (Fab-Fv) is designed to be expressed as two polypeptide chains. The heavy chain Fd fragment and light chain of an anti-Ad fiber knob antibody are fused with the VL and VH domains of an anti-CEA antibody respectively. It can form natural in vivo heterodimerization. This BsAb can retarget of adenoviral vectors to tumour cells. It can be used in cancer gene therapy to transfer a therapeutic gene into tumour cells aiming at selective and efficient cell killing.

Datasheet INQUIRY

Specifications

Targets

Ad fiber knob & CEA

Type

Fab-Fv

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Colorectal cancer (CRC); Gastric cancer; Pancreatic cancer; Lung cancer

Targets

Target 1

Ad fiber knob

Alternative Names

Ad fiber knob; Adenovirus fiber knob; adenovirus fiber protein; knob domain of Ad fiber

Target 2

CEA

Gene ID

1048

UniProt ID

A0A024R0K5

Alternative Names

CEACAM5; carcinoembryonic antigen; carcinoembryonic antigen related cell adhesion molecule 5; CEA; CD66e; meconium antigen 100

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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Recombinant Anti-Ad fiber knob x Anti-CEA Bispecific Antibody (Fab-Fv) (CAT#: FABFV-003)

Specifications

Targets

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