Recombinant Anti-Ad fiber knob x Anti-CEA Bispecific Antibody (Fab-scFv-Fc) (FABVC-003)

Recombinant Anti-Ad fiber knob x Anti-CEA Bispecific Antibody (Fab-scFv-Fc) requires expression of three polypeptide chains, encoding two heavy chains (Fc-containing chains) and one light chain, respectively. The Fab of anti-Ad fiber knob antibody variable domain is fused to the Fc-knob domain with a hinge region and the same as the scFv of anti-CEA to the Fc-hole domain, or vice versa. The Fab-Fc and scFv-Fc fragments can be paired via the interaction of the Fc regions. This BsAb can retarget of adenoviral vectors to tumour cells. It can be used in cancer gene therapy to transfer a therapeutic gene into tumour cells aiming at selective and efficient cell killing.

Datasheet INQUIRY

Specifications

Targets

Ad fiber knob & CEA

Type

Fab-Fc Fusion Proteins

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Colorectal cancer (CRC); Gastric cancer; Pancreatic cancer; Lung cancer

Targets

Target 1

Ad fiber knob

Alternative Names

Ad fiber knob; Adenovirus fiber knob; adenovirus fiber protein; knob domain of Ad fiber

Target 2

CEA

Gene ID

1048

UniProt ID

A0A024R0K5

Alternative Names

CEACAM5; carcinoembryonic antigen; carcinoembryonic antigen related cell adhesion molecule 5; CEA; CD66e; meconium antigen 100

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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Recombinant Anti-Ad fiber knob x Anti-CEA Bispecific Antibody (Fab-scFv-Fc) (CAT#: FABVC-003)

Specifications

Targets

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