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Recombinant Anti-Ad Fiber Knob x Anti-CEA Bispecific Antibody (IgG(L)-scFv)  (CAT#: IGLFV-003)

Recombinant Anti-Ad fiber knob x Anti-CEA Bispecific Antibody (IgG(L)-scFv) is formed by an IgG and two scFv moieties. The scFv fragments from an anti-Ad fiber knob antibody are fused to the C terminus of an anti-CEA IgG light (L) chains, or vice versa. It is a type of appended IgGs, which is bispecific and tetravalent (2+2 antigen-binding valency). This BsAb can retarget of adenoviral vectors to tumour cells. It can be used in cancer gene therapy to transfer a therapeutic gene into tumour cells aiming at selective and efficient cell killing.
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Specifications

Targets
Ad Fiber Knob & CEA
Type
Appended IgGs
Species Reactivity
Human
Application
FuncS; Promising therapeutic agent
Related Disease
Colorectal cancer (CRC); Gastric cancer; Pancreatic cancer; Lung cancer

Targets

Target 1
Ad Fiber Knob
Alternative Names
Ad fiber knob; Adenovirus fiber knob; adenovirus fiber protein; knob domain of Ad fiber
Target 2
CEA
Gene ID
UniProt ID
Alternative Names
CEACAM5; carcinoembryonic antigen; carcinoembryonic antigen related cell adhesion molecule 5; CEA; CD66e; meconium antigen 100
Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.
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