Name: Recombinant Anti-Ad Fiber Knob x Anti-CEA Bispecific Antibody (scFv-CH1/CL)
SKU: BSCC-003
Rating: 5 (1 reviews)

Recombinant Anti-Ad fiber knob x Anti-CEA Bispecific Antibody (scFv-CH1/CL) is designed to be expressed as two chains. One scFv from an anti-Ad fiber knob antibody variable domain is fused to CH1 and the other scFv from an anti-CEA antibody variable domain fused to CL, or vice versa. And the CH1 and CL domains are linked covalently via a natural disulfide bond. This BsAb can retarget of adenoviral vectors to tumour cells. It can be used in cancer gene therapy to transfer a therapeutic gene into tumour cells aiming at selective and efficient cell killing.

Datasheet INQUIRY

Specifications

Targets

Ad Fiber Knob & CEA

Type

scFv-CH1/CL

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Colorectal cancer (CRC); Gastric cancer; Pancreatic cancer; Lung cancer

Targets

Target 1

Ad Fiber Knob

Alternative Names

Ad fiber knob; Adenovirus fiber knob; adenovirus fiber protein; knob domain of Ad fiber

Target 2

CEA

Gene ID

1048

UniProt ID

A0A024R0K5

Alternative Names

CEACAM5; carcinoembryonic antigen; carcinoembryonic antigen related cell adhesion molecule 5; CEA; CD66e; meconium antigen 100

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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Recombinant Anti-Ad Fiber Knob x Anti-CEA Bispecific Antibody (scFv-CH1/CL) (CAT#: BSCC-003)

Specifications

Targets

Customer Reviews and Q&As