Home > Products > Ad fiber knob & CEA > Recombinant Anti-Ad fiber knob x Anti-CEA Bispecific Antibody (scFv-CH1/CL)

Recombinant Anti-Ad fiber knob x Anti-CEA Bispecific Antibody (scFv-CH1/CL)  (BSCC-003)

Recombinant Anti-Ad fiber knob x Anti-CEA Bispecific Antibody (scFv-CH1/CL) is designed to be expressed as two chains. One scFv from an anti-Ad fiber knob antibody variable domain is fused to CH1 and the other scFv from an anti-CEA antibody variable domain fused to CL, or vice versa. And the CH1 and CL domains are linked covalently via a natural disulfide bond. This BsAb can retarget of adenoviral vectors to tumour cells. It can be used in cancer gene therapy to transfer a therapeutic gene into tumour cells aiming at selective and efficient cell killing.

Specifications
Targets
Ad fiber knob & CEA
Type
scFv-CH1/CL
Species Reactivity
Human
Target 1
Ad fiber knob
Host Animal 1
Mouse
Target 2
CEA
Host Animal 2
Mouse
Application
FuncS; Promising therapeutic agent
Related Disease
Colorectal cancer (CRC); Gastric cancer; Pancreatic cancer; Lung cancer
Targets
Target 1
Ad fiber knob
Alternative Names
Ad fiber knob; Adenovirus fiber knob; adenovirus fiber protein; knob domain of Ad fiber
Target 2
CEA
Gene ID
UniProt ID
Alternative Names
CEACAM5; carcinoembryonic antigen; carcinoembryonic antigen related cell adhesion molecule 5; CEA; CD66e; meconium antigen 100
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