Home > Products > Ad fiber knob & CEA > Recombinant Anti-Ad fiber knob x Anti-CEA Bispecific Antibody (scFv-Fc)

Recombinant Anti-Ad fiber knob x Anti-CEA Bispecific Antibody (scFv-Fc)  (BSCFV-003)

Recombinant Anti-Ad fiber knob x Anti-CEA Bispecific Antibody (scFv-Fc) is formed by fusing two different scFv fragments to the hinge and Fc regions, in which the Fc region are engineered by KIH. Two of scFv moiety has the antibody variable domain of either anti-Ad fiber knob specificity or anti-CEA specificity, which produces bivalent IgG-like molecules with desired characteristics of intact antibodies. This BsAb can retarget of adenoviral vectors to tumour cells. It can be used in cancer gene therapy to transfer a therapeutic gene into tumour cells aiming at selective and efficient cell killing.

Specifications
Targets
Ad fiber knob & CEA
Type
scFv-based Bispecific Fragments
Species Reactivity
Human
Target 1
Ad fiber knob
Host Animal 1
Mouse
Target 2
CEA
Host Animal 2
Mouse
Application
FuncS; Promising therapeutic agent
Related Disease
Colorectal cancer (CRC); Gastric cancer; Pancreatic cancer; Lung cancer
Targets
Target 1
Ad fiber knob
Alternative Names
Ad fiber knob; Adenovirus fiber knob; adenovirus fiber protein; knob domain of Ad fiber
Target 2
CEA
Gene ID
UniProt ID
Alternative Names
CEACAM5; carcinoembryonic antigen; carcinoembryonic antigen related cell adhesion molecule 5; CEA; CD66e; meconium antigen 100

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