Home > Products > Ad fiber knob & CEA > Recombinant Anti-Ad fiber knob x Anti-CEA Bispecific Antibody (scFv-Fc-scFv)

Recombinant Anti-Ad fiber knob x Anti-CEA Bispecific Antibody (scFv-Fc-scFv)  (BSTF-003)

Recombinant Anti-Ad fiber knob x Anti-CEA Bispecific Antibody (scFv-Fc-scFv) is designed to be expressed as one chain, then assembled to a homodimer of bivalent scFv fragments and the Fc region of IgG. The anti-Ad fiber knob scFv is fused to the N-terminus of Fc via a hinge region while another anti-CEA scFv is linked to the C-terminus of Fc. This scFv-Fc-scFv format has 2+2 antigen-binding valency by employing different scFv fragments. This BsAb can retarget of adenoviral vectors to tumour cells. It can be used in cancer gene therapy to transfer a therapeutic gene into tumour cells aiming at selective and efficient cell killing.

Specifications
Targets
Ad fiber knob & CEA
Type
scFv-Fc-scFv
Species Reactivity
Human
Target 1
Ad fiber knob
Host Animal 1
Mouse
Target 2
CEA
Host Animal 2
Mouse
Application
FuncS; Promising therapeutic agent
Related Disease
Colorectal cancer (CRC); Gastric cancer; Pancreatic cancer; Lung cancer
Targets
Target 1
Ad fiber knob
Alternative Names
Ad fiber knob; Adenovirus fiber knob; adenovirus fiber protein; knob domain of Ad fiber
Target 2
CEA
Gene ID
UniProt ID
Alternative Names
CEACAM5; carcinoembryonic antigen; carcinoembryonic antigen related cell adhesion molecule 5; CEA; CD66e; meconium antigen 100

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