Recombinant Anti-Ad fiber knob x Anti-CEA Bispecific Antibody (Triple Body)  (TRIB-003)

Recombinant Anti-Ad fiber knob x Anti-CEA Bispecific Antibody (Triple Body) is designed to be expressed as two polypeptide chains respectively. The Fd fragment and LC from an anti-Ad fiber knob antibody are both extended with the scFv fragment from an anti-CEA antibody. This BsAb can retarget of adenoviral vectors to tumour cells. It can be used in cancer gene therapy to transfer a therapeutic gene into tumour cells aiming at selective and efficient cell killing.

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