Home > Products > Ad fiber knob & EPCAM > Recombinant Anti-Ad fiber knob x Anti-EPCAM Bispecific Antibody (TandAb)

Recombinant Anti-Ad fiber knob x Anti-EPCAM Bispecific Antibody (TandAb)  (TANDAB-004)

Recombinant Anti-Ad fiber knob x Anti-EPCAM Bispecific Antibody (TandAb) is designed to be expressed as a monomeric subunit (single chain Diabody, scDb), with four variable domains from two parental antibodies. Then the two peptide chains can dimerize in a head-to-tail fashion. This BsAb can retarget of adenoviral vectors to tumour cells. It can be used in cancer gene therapy to transfer a therapeutic gene into tumour cells aiming at selective and efficient cell killing.

Specifications
Targets
Ad fiber knob & EPCAM
Type
TandAb
Species Reactivity
Human
Target 1
Ad fiber knob
Host Animal 1
Mouse
Target 2
EPCAM
Host Animal 2
Mouse
Application
FuncS; Promising therapeutic agent
Related Disease
Breast cancer; Ovary cancer; Colon cancer; Lung cancer
Targets
Target 1
Ad fiber knob
Alternative Names
Ad fiber knob; Adenovirus fiber knob; adenovirus fiber protein; knob domain of Ad fiber
Target 2
EPCAM
Gene ID
UniProt ID
Alternative Names
EPCAM; epithelial cell adhesion molecule; ESA; KSA; M4S1; MK-1; DIAR5; EGP-2; EGP40; KS1/4; MIC18; TROP1; EGP314; HNPCC8; TACSTD1; epithelial glycoprotein 314; human epithelial glycoprotein-2; cell surface glycoprotein Trop-1; adenocarcinoma-associated antigen; tumor-associated calcium signal transducer 1; major gastrointestinal tumor-associated protein GA733-2; membrane component, chromosome 4, surface marker (35kD glycoprotein)
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