Home > Products > Ad fiber knob & ITGAV > Recombinant Anti-Ad fiber knob x Anti-ITGAV Bispecific Antibody (Fab-scFv-Fc)

Recombinant Anti-Ad fiber knob x Anti-ITGAV Bispecific Antibody (Fab-scFv-Fc)  (FABVC-005)

Recombinant Anti-Ad fiber knob x Anti-ITGAV Bispecific Antibody (Fab-scFv-Fc) requires expression of three polypeptide chains, encoding two heavy chains (Fc-containing chains) and one light chain, respectively. The Fab of anti-Ad fiber knob antibody variable domain is fused to the Fc-knob domain with a hinge region and the same as the scFv of anti-ITGAV to the Fc-hole domain, or vice versa. The Fab-Fc and scFv-Fc fragments can be paired via the interaction of the Fc regions. This BsAb can retarget of adenoviral vectors to tumour cells. It can be used in cancer gene therapy to transfer a therapeutic gene into tumour cells aiming at selective and efficient cell killing.

Specifications

Targets
Ad fiber knob & ITGAV
Type
Fab-Fc Fusion Proteins
Species Reactivity
Human
Target 1
Ad fiber knob
Host Animal 1
Mouse
Target 2
ITGAV
Host Animal 2
Mouse
Application
FuncS; Promising therapeutic agent
Related Disease
Colorectal cancer (CRC); Prostate cancer; Ovarian cancer

Targets

Target 1
Ad fiber knob
Alternative Names
Ad fiber knob; Adenovirus fiber knob; adenovirus fiber protein; knob domain of Ad fiber
Target 2
ITGAV
Gene ID
UniProt ID
Alternative Names
ITGAV; integrin, alpha V; CD51; MSK8; VNRA; VTNR; integrin alpha-V; integrin alphaVbeta3; vitronectin receptor subunit alpha; antigen identified by monoclonal antibody L230; integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)

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