Recombinant Anti-Ad fiber knob x Anti-ITGAV Bispecific Antibody (scDiabody-CH3) (SCDBC-005)

Recombinant Anti-Ad fiber knob x Anti-ITGAV Bispecific Antibody (scDiabody-CH3) is a fusion protein of two scDiabodies connected together by a CH3 region. In single-chain Diabodies, an additional connecting linker is introduced between chains of the anti-Ad fiber knob/anti-ITGAV diabody. The scDiabody with two specificities is fused to each of the CH3 chains to extend half-life. This BsAb can retarget of adenoviral vectors to tumour cells. It can be used in cancer gene therapy to transfer a therapeutic gene into tumour cells aiming at selective and efficient cell killing.

Datasheet INQUIRY

Specifications

Targets

Ad fiber knob & ITGAV

Type

Constant Domain-extended Bispecific Fragments

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Colorectal cancer (CRC); Prostate cancer; Ovarian cancer

Targets

Target 1

Ad fiber knob

Alternative Names

Ad fiber knob; Adenovirus fiber knob; adenovirus fiber protein; knob domain of Ad fiber

Target 2

ITGAV

Gene ID

3685

UniProt ID

P06756

Alternative Names

ITGAV; integrin, alpha V; CD51; MSK8; VNRA; VTNR; integrin alpha-V; integrin alphaVbeta3; vitronectin receptor subunit alpha; antigen identified by monoclonal antibody L230; integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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Recombinant Anti-Ad fiber knob x Anti-ITGAV Bispecific Antibody (scDiabody-CH3) (CAT#: SCDBC-005)

Specifications

Targets

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