Recombinant Anti-Ad fiber knob x Anti-ITGAV Bispecific Antibody (scFv-IgG) (BSSG-005)

Recombinant Anti-Ad fiber knob x Anti-ITGAV Bispecific Antibody (scFv-IgG) is formed by an IgG and two scFv fragments. The scFvs from an anti-Ad fiber knob antibody variable domain are respectively connected to the N terminus of the anti-ITGAV IgG heavy chains or light chains to form scFv-(H)IgG or scFv-(L)IgG. It is a type of appended IgGs and has 2+2 antigen-binding valency. This BsAb can retarget of adenoviral vectors to tumour cells. It can be used in cancer gene therapy to transfer a therapeutic gene into tumour cells aiming at selective and efficient cell killing.

Datasheet INQUIRY

Specifications

Targets

Ad fiber knob & ITGAV

Type

Appended IgGs

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Colorectal cancer (CRC); Prostate cancer; Ovarian cancer

Targets

Target 1

Ad fiber knob

Alternative Names

Ad fiber knob; Adenovirus fiber knob; adenovirus fiber protein; knob domain of Ad fiber

Target 2

ITGAV

Gene ID

3685

UniProt ID

P06756

Alternative Names

ITGAV; integrin, alpha V; CD51; MSK8; VNRA; VTNR; integrin alpha-V; integrin alphaVbeta3; vitronectin receptor subunit alpha; antigen identified by monoclonal antibody L230; integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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Recombinant Anti-Ad fiber knob x Anti-ITGAV Bispecific Antibody (scFv-IgG) (CAT#: BSSG-005)

Specifications

Targets

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