Recombinant Human Anti-albumin x Human Anti-IL-6R Bispecific Antibody (Diabody-CH3) (BSDBC-H194)

Recombinant Anti-albumin x Anti-IL-6R Bispecific Antibody (Diabody-CH3) is a fusion protein of two diabodies connected together by a CH3 region. In a diabody, the two scFvs with short linkers are from anti-albumin and anti-IL-6R antibodies. The VH and VL domains form an inter-chain pairing. The diabody with different specificities is fused to each of the CH3 chains, which results in 2+2 antigen-binding valency and extends the half-life of this BsAb. This BsAb can act as PK-modulated receptor antagonist. It is designed for the research of Lupus, rheumatoid arthritis therapy.

Datasheet INQUIRY

Specifications

Targets

albumin & IL-6R

Type

Constant Domain-extended Bispecific Fragments

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Systemic lupus erythematosus (SLE); Rheumatoid arthritis (RA)

Targets

Target 1

albumin

Gene ID

213

UniProt ID

P02768

Alternative Names

ALB; albumin; HAS; PRO0883; PRO0903; PRO1341

Target 2

IL-6R

Gene ID

3570

UniProt ID

P08887

Alternative Names

IL6R; IL-6R; interleukin 6 receptor; IL6Q; gp80; CD126; IL6RA; IL6RQ; IL-6RA; IL-6R-1

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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Recombinant Human Anti-albumin x Human Anti-IL-6R Bispecific Antibody (Diabody-CH3) (CAT#: BSDBC-H194)

Specifications

Targets

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