Recombinant Anti-albumin x Anti-IL-6R Bispecific Antibody (IgG-Fv) is formed by an Immunoglobulin G (IgG) and a fragment variable Fv region, in which the Fc of IgG is engineered by KIH. The Fv region of an anti-albumin antibody variable domain is fused to the C terminal of an IgG of anti-IL-6R antibody, or vice versa. The format retains desired characteristics of intact antibodies. This BsAb can act as PK-modulated receptor antagonist. It is designed for the research of Lupus, rheumatoid arthritis therapy.