Home > Products > albumin & IL-6R > Recombinant Human Anti-albumin x Human Anti-IL-6R Bispecific Antibody (scFv-CH3)

Recombinant Human Anti-albumin x Human Anti-IL-6R Bispecific Antibody (scFv-CH3)  (BSFC-H194)

Recombinant Anti-albumin x Anti-IL-6R Bispecific Antibody (scFv-CH3) contains two chains. The anti-albumin scFv is fused to the Knob-CH3 domain via a hinge region and the same as the anti-IL-6R scFv to the Hole-CH3 domain, or vice versa. The KIH CH3 domains can facilitate to form a heterodimer and this bivalent binding leads to improvement in avidity. This BsAb can act as PK-modulated receptor antagonist. It is designed for the research of Lupus, rheumatoid arthritis therapy.

Specifications
Targets
albumin & IL-6R
Type
scFv-based Bispecific Fragments
Species Reactivity
Human
Target 1
albumin
Host Animal 1
Mouse
Target 2
IL-6R
Host Animal 2
Mouse
Application
FuncS; Promising therapeutic agent
Related Disease
Systemic lupus erythematosus (SLE); Rheumatoid arthritis (RA)
Targets
Target 1
albumin
Gene ID
UniProt ID
Alternative Names
ALB; albumin; HAS; PRO0883; PRO0903; PRO1341
Target 2
IL-6R
Gene ID
UniProt ID
Alternative Names
IL6R; IL-6R; interleukin 6 receptor; IL6Q; gp80; CD126; IL6RA; IL6RQ; IL-6RA; IL-6R-1
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