Recombinant Anti-albumin x Anti-IL-6R Bispecific Antibody (VHH-Fc-VHH, Tetravalent HCAb) is a fusion protein of two diabodies connected together by an Fc region. In a diabody, the two VHHs with short linkers are from anti-albumin and anti-IL-6R antibodies. The VH and VL domains form an inter-chain pairing. The diabody with different specificities is fused to the Fc fragment, which results in 2+2 antigen-binding valency and exerts Fc-mediated functions or just extends the half-life. This BsAb can act as PK-modulated receptor antagonist. It is designed for the research of Systemic lupus erythematosus (SLE); Rheumatoid arthritis (RA).
Constant Domain-extended Bispecific Fragments
FuncS; Promising therapeutic agent
Systemic lupus erythematosus (SLE); Rheumatoid arthritis (RA)
ALB; albumin; HAS; PRO0883; PRO0903; PRO1341
TNF; tumor necrosis factor; DIF; TNFA; TNFSF2; TNF-alpha; TNFα; cachectin; APC1 protein; TNF, monocyte-derived; TNF-α; TNF, macrophage-derived; tumor necrosis factor-alpha; tumor necrosis factor ligand superfamily member 2
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