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Recombinant Human Anti-albumin x Human Anti-TNF Bispecific Antibody (Diabody-CH3)  (BSDBC-H195)

Recombinant Anti-albumin x Anti-TNF Bispecific Antibody (Diabody-CH3) is a fusion protein of two diabodies connected together by a CH3 region. In a diabody, the two scFvs with short linkers are from anti-albumin and anti-TNF antibodies. The VH and VL domains form an inter-chain pairing. The diabody with different specificities is fused to each of the CH3 chains, which results in 2+2 antigen-binding valency and extends the half-life of this BsAb. This BsAb can act as PK-modulated ligand antagonist. It is designed for the research of Lupus and rheumatoid arthritis therapy.

Specifications

Targets
albumin & TNF
Type
Constant Domain-extended Bispecific Fragments
Species Reactivity
Human
Target 1
albumin
Host Animal 1
Human
Target 2
TNF
Host Animal 2
Human
Application
FuncS; Promising therapeutic agent
Related Disease
Systemic lupus erythematosus (SLE); Rheumatoid arthritis (RA)

Targets

Target 1
albumin
Gene ID
UniProt ID
Alternative Names
ALB; albumin; HAS; PRO0883; PRO0903; PRO1341
Target 2
TNF
Gene ID
UniProt ID
Alternative Names
TNF; tumor necrosis factor; DIF; TNFA; TNFSF2; TNF-alpha; TNFα; cachectin; APC1 protein; TNF, monocyte-derived; TNF-α; TNF, macrophage-derived; tumor necrosis factor-alpha; tumor necrosis factor ligand superfamily member 2

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