Recombinant Anti-albumin x Anti-TNF Bispecific Antibody (Diabody-Fc) (BSDBF-007)

Recombinant Anti-albumin x Anti-TNF Bispecific Antibody (Diabody-Fc) is a fusion protein of two diabodies connected together by an Fc region. In a diabody, the two scFvs with short linkers are from anti-albumin and anti-TNF antibodies. The VH and VL domains form an inter-chain pairing. The diabody with different specificities is fused to the Fc fragment, which results in 2+2 antigen-binding valency and exerts Fc-mediated functions or just extends the half-life. This BsAb can act as PK-modulated ligand antagonist. It is designed for the research of Lupus and rheumatoid arthritis therapy.

Datasheet INQUIRY

Specifications

Targets

albumin & TNF

Type

Constant Domain-extended Bispecific Fragments

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Systemic lupus erythematosus (SLE); Rheumatoid arthritis (RA)

Targets

Target 1

albumin

Gene ID

213

UniProt ID

P02768

Alternative Names

ALB; albumin; HAS; PRO0883; PRO0903; PRO1341

Target 2

TNF

Gene ID

7124

UniProt ID

P01375

Alternative Names

TNF; tumor necrosis factor; DIF; TNFA; TNFSF2; TNF-alpha; TNFα; cachectin; APC1 protein; TNF, monocyte-derived; TNF-α; TNF, macrophage-derived; tumor necrosis factor-alpha; tumor necrosis factor ligand superfamily member 2

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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Recombinant Anti-albumin x Anti-TNF Bispecific Antibody (Diabody-Fc) (CAT#: BSDBF-007)

Specifications

Targets

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