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Recombinant Human Anti-albumin x Human Anti-TNF Bispecific Antibody (scFv-Fc-scFv)  (BSTF-H195)

Recombinant Anti-albumin x Anti-TNF Bispecific Antibody (scFv-Fc-scFv) is designed to be expressed as one chain, then assembled to a homodimer of bivalent scFv fragments and the Fc region of IgG. The anti-albumin scFv is fused to the N-terminus of Fc via a hinge region while another anti-TNF scFv is linked to the C-terminus of Fc. This scFv-Fc-scFv format has 2+2 antigen-binding valency by employing different scFv fragments. This BsAb can act as PK-modulated ligand antagonist. It is designed for the research of Lupus and rheumatoid arthritis therapy.

Specifications

Targets
albumin & TNF
Type
scFv-based Bispecific Fragments
Species Reactivity
Human
Target 1
albumin
Host Animal 1
Mouse
Target 2
TNF
Host Animal 2
Mouse
Application
FuncS; Promising therapeutic agent
Related Disease
Systemic lupus erythematosus (SLE); Rheumatoid arthritis (RA)

Targets

Target 1
albumin
Gene ID
UniProt ID
Alternative Names
ALB; albumin; HAS; PRO0883; PRO0903; PRO1341
Target 2
TNF
Gene ID
UniProt ID
Alternative Names
TNF; tumor necrosis factor; DIF; TNFA; TNFSF2; TNF-alpha; TNFα; cachectin; APC1 protein; TNF, monocyte-derived; TNF-α; TNF, macrophage-derived; tumor necrosis factor-alpha; tumor necrosis factor ligand superfamily member 2

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