Home > Products > Ang2 & VEGFA > Recombinant Human Anti-Ang2 x Human Anti-VEGFA Bispecific Antibody (Diabody-CH3)

Recombinant Human Anti-Ang2 x Human Anti-VEGFA Bispecific Antibody (Diabody-CH3)  (BSDBC-H196)

Recombinant Anti-Ang2 x Anti-VEGFA Bispecific Antibody (Diabody-CH3) is a fusion protein of two diabodies connected together by a CH3 region. In a diabody, the two scFvs with short linkers are from anti-Ang2 and anti-VEGFA antibodies. The VH and VL domains form an inter-chain pairing. The diabody with different specificities is fused to each of the CH3 chains, which results in 2+2 antigen-binding valency and extends the half-life of this BsAb. This BsAb is capable of inhibiting two proangiogenics fators and a combined blockade of them has a greater inhibitory efficacy compared with inhibition of either factor alone. It is designed for the research of Colorectal cancer (CRC); Solid tumors; Wet AMD (Age-related macular degeneration); Diabetic macular edema therapy.

Specifications

Targets
Ang2 & VEGFA
Type
Constant Domain-extended Bispecific Fragments
Species Reactivity
Human
Target 1
Ang2
Host Animal 1
Human
Target 2
VEGFA
Host Animal 2
Human
Application
FuncS; Promising therapeutic agent
Related Disease
Colorectal cancer (CRC); Solid tumors; Wet AMD (Age-related macular degeneration); Diabetic macular edema

Targets

Target 1
Ang2
Gene ID
UniProt ID
Alternative Names
ANGPT2; Ang2; angiopoietin 2; ANG2; AGPT2; angiopoietin-2; ANG-2; Tie2-ligand; angiopoietin-2B; angiopoietin-2a
Target 2
VEGFA
Gene ID
UniProt ID
Alternative Names
VEGFA; vascular endothelial growth factor A; VPF; VEGF; MVCD1; vascular permeability factor

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