Home > Products > Ang2 & VEGFA > Recombinant Anti-Ang2 x Anti-VEGFA Bispecific Antibody (F(ab')2-scFv2)

Recombinant Anti-Ang2 x Anti-VEGFA Bispecific Antibody (F(ab')2-scFv2)  (BABFV-008)

Recombinant Anti-Ang2 x Anti-VEGFA Bispecific Antibody (F(ab')2-scFv2) is designed to be expressed as two chains combined via a hinge region. The scFv of the anti-Ang2 specificity is fused to the C terminus of the anti-VEGFA Fab fragment, or vice versa. This format comprises four binding sites (two same scFv regions and two same Fab fragments), two for each antigen. This BsAb is capable of inhibiting two proangiogenics fators and a combined blockade of them has a greater inhibitory efficacy compared with inhibition of either factor alone. It is designed for the research of Colorectal cancer (CRC); Solid tumors; Wet AMD (Age-related macular degeneration); Diabetic macular edema therapy.

Specifications

Targets
Ang2 & VEGFA
Type
Fab-Fc Fusion Proteins
Species Reactivity
Human
Target 1
Ang2
Host Animal 1
Mouse
Target 2
VEGFA
Host Animal 2
Mouse
Application
FuncS; Promising therapeutic agent
Related Disease
Colorectal cancer (CRC); Solid tumors; Wet AMD (Age-related macular degeneration); Diabetic macular edema

Targets

Target 1
Ang2
Gene ID
UniProt ID
Alternative Names
ANGPT2; Ang2; angiopoietin 2; ANG2; AGPT2; angiopoietin-2; ANG-2; Tie2-ligand; angiopoietin-2B; angiopoietin-2a
Target 2
VEGFA
Gene ID
UniProt ID
Alternative Names
VEGFA; vascular endothelial growth factor A; VPF; VEGF; MVCD1; vascular permeability factor

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