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Recombinant Anti-Ang2 x Anti-VEGFA Bispecific Antibody (Fab-Fv) (CAT#: FABFV-008)
Recombinant Anti-Ang2 x Anti-VEGFA Bispecific Antibody (Fab-Fv) is designed to be expressed as two polypeptide chains. The heavy chain Fd fragment and light chain of an anti-Ang2 antibody are fused with the VL and VH domains of an anti-VEGFA antibody respectively. It can form natural in vivo heterodimerization. This BsAb is capable of inhibiting two proangiogenics fators and a combined blockade of them has a greater inhibitory efficacy compared with inhibition of either factor alone. It is designed for the research of Colorectal cancer (CRC); Solid tumors; Wet AMD (Age-related macular degeneration); Diabetic macular edema therapy.
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