Home > Products > Ang2 & VEGFA > Recombinant Human Anti-Ang2 x Anti-VEGFA Bispecific Antibody (Fab-IgG)

Recombinant Human Anti-Ang2 x Anti-VEGFA Bispecific Antibody (Fab-IgG)  (FABIG-H194)

Recombinant Anti-Ang2 x Anti-VEGFA Bispecific Antibody (Fab-IgG) is designed to be expressed as three chains, assembling in vivo and resulting in the construct of Fab-IgG (Tandem Fab-Fc). Fab-IgG has standard Fab and Fc domains, with no mutations, which may permit it has similar affinity binding and PK profile comparable to the parental antibodies. This BsAb is capable of inhibiting two proangiogenics fators and a combined blockade of them has a greater inhibitory efficacy compared with inhibition of either factor alone. It is designed for the research of Colorectal cancer (CRC); Solid tumors; Wet AMD (Age-related macular degeneration); Diabetic macular edema therapy.

Specifications

Targets
Ang2 & VEGFA
Type
Fab-IgG
Species Reactivity
Human
Target 1
Ang2
Host Animal 1
Human
Target 2
VEGFA
Host Animal 2
Human
Application
FuncS; Promising therapeutic agent
Related Disease
Colorectal cancer (CRC)Solid tumors Wet AMD (Age-related macular degeneration); Diabetic macular edema

Targets

Target 1
Ang2
Gene ID
UniProt ID
Alternative Names
ANGPT2; Ang2; angiopoietin 2; ANG2; AGPT2; angiopoietin-2; ANG-2; Tie2-ligand; angiopoietin-2B; angiopoietin-2a
Target 2
VEGFA
Gene ID
UniProt ID
Alternative Names
VEGFA; vascular endothelial growth factor A; VPF; VEGF; MVCD1; vascular permeability factor

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Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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