Home > Products > Ang2 & VEGFA > Recombinant Anti-Ang2 x Anti-VEGFA Bispecific Antibody (Fab-scFv-Fc)

Recombinant Anti-Ang2 x Anti-VEGFA Bispecific Antibody (Fab-scFv-Fc)  (FABVC-008)

Recombinant Anti-Ang2 x Anti-VEGFA Bispecific Antibody (Fab-scFv-Fc) requires expression of three polypeptide chains, encoding two heavy chains (Fc-containing chains) and one light chain, respectively. The Fab of anti-Ang2 antibody variable domain is fused to the Fc-knob domain with a hinge region and the same as the scFv of anti-VEGFA to the Fc-hole domain, or vice versa. The Fab-Fc and scFv-Fc fragments can be paired via the interaction of the Fc regions. This BsAb is capable of inhibiting two proangiogenics fators and a combined blockade of them has a greater inhibitory efficacy compared with inhibition of either factor alone. It is designed for the research of Colorectal cancer (CRC); Solid tumors; Wet AMD (Age-related macular degeneration); Diabetic macular edema therapy.

Specifications

Targets
Ang2 & VEGFA
Type
Fab-Fc Fusion Proteins
Species Reactivity
Human
Target 1
Ang2
Host Animal 1
Mouse
Target 2
VEGFA
Host Animal 2
Mouse
Application
FuncS; Promising therapeutic agent
Related Disease
Colorectal cancer (CRC); Solid tumors; Wet AMD (Age-related macular degeneration); Diabetic macular edema

Targets

Target 1
Ang2
Gene ID
UniProt ID
Alternative Names
ANGPT2; Ang2; angiopoietin 2; ANG2; AGPT2; angiopoietin-2; ANG-2; Tie2-ligand; angiopoietin-2B; angiopoietin-2a
Target 2
VEGFA
Gene ID
UniProt ID
Alternative Names
VEGFA; vascular endothelial growth factor A; VPF; VEGF; MVCD1; vascular permeability factor

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