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Recombinant Anti-Ang2 x Anti-VEGFA Bispecific Antibody (IgG-Fv) (CAT#: BSGV-008)
Recombinant Anti-Ang2 x Anti-VEGFA Bispecific Antibody (IgG-Fv) is formed by an Immunoglobulin G (IgG) and a fragment variable Fv region, in which the Fc of IgG is engineered by KIH. The Fv region of an anti-Ang2 antibody variable domain is fused to the C terminal of an IgG of anti-VEGFA antibody, or vice versa. The format retains desired characteristics of intact antibodies. This BsAb is capable of inhibiting two proangiogenics fators and a combined blockade of them has a greater inhibitory efficacy compared with inhibition of either factor alone. It is designed for the research of Colorectal cancer (CRC); Solid tumors; Wet AMD (Age-related macular degeneration); Diabetic macular edema therapy.
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