Recombinant Anti-Ang2 x Anti-VEGFA Bispecific Antibody (scFv-CH1/CL) is designed to be expressed as two chains. One scFv from an anti-Ang2 antibody variable domain is fused to CH1 and the other scFv from an anti-VEGFA antibody variable domain fused to CL, or vice versa. And the CH1 and CL domains are linked covalently via a natural disulfide bond. This BsAb is capable of inhibiting two proangiogenics fators and a combined blockade of them has a greater inhibitory efficacy compared with inhibition of either factor alone. It is designed for the research of Colorectal cancer (CRC); Solid tumors; Wet AMD (Age-related macular degeneration); Diabetic macular edema therapy.
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