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Recombinant Anti-Ang2 x Anti-VEGFA Bispecific Antibody (scFv-Fc) (CAT#: BSCFV-008)
Recombinant Anti-Ang2 x Anti-VEGFA Bispecific Antibody (scFv-Fc) is formed by fusing two different scFv fragments to the hinge and Fc regions, in which the Fc region are engineered by KIH. Two of scFv moiety has the antibody variable domain of either anti-Ang2 specificity or anti-VEGFA specificity, which produces bivalent IgG-like molecules with desired characteristics of intact antibodies. This BsAb is capable of inhibiting two proangiogenics fators and a combined blockade of them has a greater inhibitory efficacy compared with inhibition of either factor alone. It is designed for the research of Colorectal cancer (CRC); Solid tumors; Wet AMD (Age-related macular degeneration); Diabetic macular edema therapy.
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