Home > Products > Ang2 & VEGFA > Recombinant Anti-Ang2 x Anti-VEGFA Bispecific Antibody (scFv-Fc-scFv)

Recombinant Anti-Ang2 x Anti-VEGFA Bispecific Antibody (scFv-Fc-scFv)  (BSTF-008)

Recombinant Anti-Ang2 x Anti-VEGFA Bispecific Antibody (scFv-Fc-scFv) is designed to be expressed as one chain, then assembled to a homodimer of bivalent scFv fragments and the Fc region of IgG. The anti-Ang2 scFv is fused to the N-terminus of Fc via a hinge region while another anti-VEGFA scFv is linked to the C-terminus of Fc. This scFv-Fc-scFv format has 2+2 antigen-binding valency by employing different scFv fragments. This BsAb is capable of inhibiting two proangiogenics fators and a combined blockade of them has a greater inhibitory efficacy compared with inhibition of either factor alone. It is designed for the research of Colorectal cancer (CRC); Solid tumors; Wet AMD (Age-related macular degeneration); Diabetic macular edema therapy.

Specifications

Targets
Ang2 & VEGFA
Type
scFv-based Bispecific Fragments
Species Reactivity
Human
Target 1
Ang2
Host Animal 1
Mouse
Target 2
VEGFA
Host Animal 2
Mouse
Application
FuncS; Promising therapeutic agent
Related Disease
Colorectal cancer (CRC); Solid tumors; Wet AMD (Age-related macular degeneration); Diabetic macular edema

Targets

Target 1
Ang2
Gene ID
UniProt ID
Alternative Names
ANGPT2; Ang2; angiopoietin 2; ANG2; AGPT2; angiopoietin-2; ANG-2; Tie2-ligand; angiopoietin-2B; angiopoietin-2a
Target 2
VEGFA
Gene ID
UniProt ID
Alternative Names
VEGFA; vascular endothelial growth factor A; VPF; VEGF; MVCD1; vascular permeability factor

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