Recombinant Anti-Ang2 x Anti-VEGFA Bispecific Antibody (scFv-Fc-scFv) is designed to be expressed as one chain, then assembled to a homodimer of bivalent scFv fragments and the Fc region of IgG. The anti-Ang2 scFv is fused to the N-terminus of Fc via a hinge region while another anti-VEGFA scFv is linked to the C-terminus of Fc. This scFv-Fc-scFv format has 2+2 antigen-binding valency by employing different scFv fragments. This BsAb is capable of inhibiting two proangiogenics fators and a combined blockade of them has a greater inhibitory efficacy compared with inhibition of either factor alone. It is designed for the research of Colorectal cancer (CRC); Solid tumors; Wet AMD (Age-related macular degeneration); Diabetic macular edema therapy.
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