Recombinant Anti-Ang2 x Anti-VEGFA Bispecific Antibody (scFv-IgG) is formed by an IgG and two scFv fragments. The scFvs from an anti-Ang2 antibody variable domain are respectively connected to the N terminus of the anti-VEGFA IgG heavy chains or light chains to form scFv-(H)IgG or scFv-(L)IgG. It is a type of appended IgGs and has 2+2 antigen-binding valency. This BsAb is capable of inhibiting two proangiogenics fators and a combined blockade of them has a greater inhibitory efficacy compared with inhibition of either factor alone. It is designed for the research of Colorectal cancer (CRC); Solid tumors; Wet AMD (Age-related macular degeneration); Diabetic macular edema therapy.
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