Name: Recombinant Anti-Ang2 x Anti-VEGFA Bispecific Antibody (sdAb-IgG)
SKU: BSSG-358
Rating: 5 (1 reviews)

Recombinant Anti-Ang2 x Anti-VEGFA Bispecific Antibody (sdAb-IgG) is formed by an IgG and two single domains antibodies (sdAbs). The sdAbs from an anti-VEGFA antibody variable domain are respectively connected to the N terminus of the anti-Ang2 IgG heavy chains or light chains to form sdAb-(H)IgG or sdAb-(L)IgG. It is a type of appended IgGs and has 2+2 antigen-binding valency. This BsAb is capable of inhibiting two proangiogenics fators and a combined blockade of them has a greater inhibitory efficacy compared with inhibition of either factor alone. It is designed for the research of Colorectal cancer (CRC); Solid tumors; Wet AMD (Age-related macular degeneration); Diabetic macular edema therapy.

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Specifications

Targets

Ang2 & VEGFA

Type

sdAb-IgG

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Colorectal cancer (CRC); Solid tumors; Wet AMD (Age-related macular degeneration); Diabetic macular edema

Host Animal 1

Mouse

Host Animal 2

llama

Targets

Target 1

Ang2

Gene ID

285

UniProt ID

O15123

Alternative Names

ANGPT2; Ang2; angiopoietin 2; ANG2; AGPT2; angiopoietin-2; ANG-2; Tie2-ligand; angiopoietin-2B; angiopoietin-2a

Target 2

VEGFA

Gene ID

7422

UniProt ID

P15692

Alternative Names

VEGFA; vascular endothelial growth factor A; VPF; VEGF; MVCD1; vascular permeability factor

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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Recombinant Anti-Ang2 x Anti-VEGFA Bispecific Antibody (sdAb-IgG) (CAT#: BSSG-358)

Specifications

Targets

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