Recombinant Anti-B cell lymphoma BCL1 Idiotype x Anti-CD3 Bispecific Antibody (scFv-Fc-scFv) is designed to be expressed as one chain, then assembled to a homodimer of bivalent scFv fragments and the Fc region of IgG. The anti-B cell lymphoma BCL1 Idiotype scFv is fused to the N-terminus of Fc via a hinge region while another anti-CD3 scFv is linked to the C-terminus of Fc. This scFv-Fc-scFv format has 2+2 antigen-binding valency by employing different scFv fragments. This BsAb can block cell adhesion. It is designed for the research of B cell lymphoma therapy.
Specifications
Targets
B cell lymphoma BCL1 Idiotype & CD3
Type
scFv-based Bispecific Fragments
Target 1
B cell lymphoma BCL1 Idiotype
Application
FuncS; Promising therapeutic agent
Related Disease
B cell lymphoma
Targets
Target 1
B cell lymphoma BCL1 Idiotype
Alternative Names
B cell lymphoma BCL1 Idiotype; B cell lymphoma; BCL1; Idiotype; Id; 31D1; 32D1
Alternative Names
CD3; CD3E; CD3e molecule; Cluster of differentiation 3; CD3e molecule, epsilon (CD3-TCR complex); T3E; TCRE; IMD18; T-cell surface glycoprotein CD3 epsilon chain; CD3-epsilon; T-cell surface antigen T3/Leu-4 epsilon chain; CD3e antigen, epsilon polypeptide (TiT3 complex); T-cell antigen receptor complex, epsilon subunit of T3; AI504783
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