Name: Recombinant Human Anti-B7H3 x Human Anti-4-1BB Bispecific Antibody (IgG(H)-scFv)
SKU: KN-0825-N10
Rating: 5 (1 reviews)

Recombinant Human Anti-B7H3 x Human Anti-4-1BB Bispecific Antibody (IgG(H)-scFv) is designed to be expressed as a LC and an extended HC with scFv moiety linked to the C terminus. The anti-4-1BB scFvs are fused to the C terminus of the anti-B7H3 IgG-Fc chain. It is a symmetric bispecific and tetravalent molecule, bivalent for each antigen specificity, 2+2 antigen-binding valency. This BsAb can activate 4-1BB signaling, leading to T cell activation against B7H3-overexpressing tumors. It is designed for the research of Solid tumors therapy.

Datasheet INQUIRY

Specifications

Targets

B7H3 & 4-1BB

Type

IgG-scFv

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Solid tumors

Host Animal 1

Human

Host Animal 2

Human

Targets

Target 1

B7H3

Gene ID

80381

UniProt ID

Q5ZPR3

Alternative Names

B7H3; B7 homolog 3; CD276; CD276 molecule; B7-H3; B7RP-2; 4Ig-B7-H3; B7-related protein 2; B7RP2; B7 homologue 3

Target 2

4-1BB

Gene ID

3604

UniProt ID

Q07011

Alternative Names

CD137; Cluster of Differentiation 137; 4-1BB; 4-1BB Receptor; ILA; Induced by Lymphocyte Activation; T-cell Antigen 4-1BB Homolog; CDw137; IMD109; 4-1BB ligand receptor; Tumor necrosis factor receptor superfamily member 9; T-cell antigen ILA

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

Online Inquiry

Customer Reviews and Q&As

There are currently no customer reviews or questions for Recombinant Human Anti-B7H3 x Human Anti-4-1BB Bispecific Antibody (IgG(H)-scFv) (KN-0825-N10). Click the button below to contact us or submit your feedback about this product.

Recombinant Human Anti-B7H3 x Human Anti-4-1BB Bispecific Antibody (IgG(H)-scFv) (CAT#: KN-0825-N10)

Specifications

Targets

Customer Reviews and Q&As