Home > Products > B7H6 & CD3 > Recombinant Anti-B7H6 x Anti-CD3 Bispecific Antibody (scFv-CH3)

Recombinant Anti-B7H6 x Anti-CD3 Bispecific Antibody (scFv-CH3)  (BSFC-017)

Recombinant Anti-B7H6 x Anti-CD3 Bispecific Antibody (scFv-CH3) contains two chains. The anti-B7H6 scFv is fused to the Knob-CH3 domain via a hinge region and the same as the anti-CD3 scFv to the Hole-CH3 domain, or vice versa. The KIH CH3 domains can facilitate to form a heterodimer and this bivalent binding leads to improvement in avidity. This BsAb can retarget T cells to tumor cells. It is designed for the research of Hematologic neoplasms; Solid tumors therapy.

Specifications
Targets
B7H6 & CD3
Type
scFv-based Bispecific Fragments
Species Reactivity
Human
Target 1
B7H6
Host Animal 1
Mouse
Target 2
CD3
Host Animal 2
Mouse
Application
FuncS; Promising therapeutic agent
Related Disease
Hematologic neoplasms; Solid tumors
Targets
Target 1
B7H6
Gene ID
UniProt ID
Alternative Names
NCR3LG1; natural killer cell cytotoxicity receptor 3 ligand 1; B7H6; B7-H6; DKFZp686O24166; natural cytotoxicity triggering receptor 3 ligand 1; B7 homolog 6; putative Ig-like domain-containing protein DKFZp686O24166/DKFZp686I21167
Target 2
CD3
Gene ID
UniProt ID
Alternative Names
CD3; CD3E; CD3e molecule; Cluster of differentiation 3; CD3e molecule, epsilon (CD3-TCR complex); T3E; TCRE; IMD18; T-cell surface glycoprotein CD3 epsilon chain; CD3-epsilon; T-cell surface antigen T3/Leu-4 epsilon chain; CD3e antigen, epsilon polypeptide (TiT3 complex); T-cell antigen receptor complex, epsilon subunit of T3
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