Recombinant Anti-B7H6 x Anti-CD3 Bispecific Antibody (Tandem Fab) (BSFAB-017)

Recombinant Anti-B7H6 x Anti-CD3 Bispecific Antibody (Tandem Fab) is designed to be expressed as three chains derived from the variable domains of anti-B7H6 and anti-CD3 parental antibodies. It contains a His-tag for affinity purification. And the two Fd regions are connected by a flexible linker. This BsAb can retarget T cells to tumor cells. It is designed for the research of Hematologic neoplasms; Solid tumors therapy.

Datasheet

Specifications

Targets

B7H6 & CD3

Type

Tandem Fab

Species Reactivity

Human

Target 1

B7H6

Host Animal 1

Mouse

Target 2

CD3

Host Animal 2

Mouse

Application

FuncS; Promising therapeutic agent

Related Disease

Hematologic neoplasms; Solid tumors

Targets

Target 1

B7H6

Gene ID

374383

UniProt ID

Q68D85

Alternative Names

NCR3LG1; natural killer cell cytotoxicity receptor 3 ligand 1; B7H6; B7-H6; DKFZp686O24166; natural cytotoxicity triggering receptor 3 ligand 1; B7 homolog 6; putative Ig-like domain-containing protein DKFZp686O24166/DKFZp686I21167

Target 2

CD3

Gene ID

916

UniProt ID

P07766

Alternative Names

C3AR1; complement C3a receptor 1; AZ3B; C3AR; HNFAG09; CR3; Complement receptor type 3; CD11b/CD18; Mac-1; Macrophage antigen 1; αmβ2

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